Cancer Biology and MicroRNAs Essay Example | Topics and Well Written Essays - 500 words

Cancer Biology and MicroRNAs - Essay ExampleThese various RNAs then decide how the amino acids will be coded to make the final protein chain and hence the expression of the genes. MicroRNAs however, argon non-coding which means that they are not involved in the transcription and the translation process in any way. They are sensitive molecules and they contain about twenty to twenty-five nucleotides. The role of the micro RNAs is to regulate gene expression as the work of the coding RNA needs to be streamlined to avoid abnormal or handle coding. They are too very important in RNA silencing which involves suppressing the effect of a gene or more than one gene after coding has taken place (Dutta & Lee, 2010). This stand also be important in the elimination of certain unwanted genes form the body. RNA silencing involves the use of antisense RNA which is employ in the gene silencing. The identification of the two were among the greatest works done in this field in the last century. Of more splendour is the realization that miRNA were signifi fuckt hearteners in the etiology of cancer. Further studies have shown that the miRNAs can be utilize in cancer therapy and so cause their nature existence and roles is of great importance to molecular biology. miRNAs are often expressed differently in various stages of development in the being an aspect that made them be called small temporal RNA due to their temporary expression (Dutta & Lee, 2010). The techniques used to measure their expression include Northern blotting and primer extension assay. This has been developed to help in understanding the small aspects of DNA and RNA that scientists could have ignored or bypassed in the past. As highlighted earlier, micro RNAs play a role in suppressing target messenger RNA expression. This is a complex interaction which includes interacting with 3UTR in the mRNA. What has been noted is that there are many mismatches in the micro RNA target sites a situationthat is stil l being probed to establish the cause and effects in gene mRNA expression. miRNA is also known to inhibit or decrease the target levels in the respective mRNA and so this can affect the organism adversely or serve as a predisposing factor for cancer.